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Systematic Reviews: Search Strategies

Provides an overview of the Systematic Review process and offers information on standards and best practices.

Collaborate with a Librarian

It is highly recommend that you collaborate with a librarian on developing your search strategy. Librarians are experts on identifying appropriate databases, developing comprehensive search strategies, writing the search methodology, and providing documentation for the line-by-line search strategies for use in the manuscript appendices.

According to the National Academies of Sciences, Engineering, Medicine: Standards for Systematic Reviews Standard 2.1.3, the review team should "include expertise in searching for relevant evidence".

Databases and Grey Literature

The most common databases used for systematic reviews include: PubMed, Embase, Cochrane, SCOPUS, CINAHL, SciFinder, and PsycINFO

Grey Literature must also be searched. Grey Literature is defined as materials and research produced by organizations outside of the traditional commercial or academic publishing and distribution channels. This would include publications such as conference proceedings, technical reports, theses, dissertations, and government documents.

Below is a list of the most commonly used databases. We also recommend that you consult your discipline's research guide and consult your librarian for database suggestions. 

link to PubMed PubMed: Clinical biomedicine database

 

link to Cochrane Library Cochrane Library: Systematic review database

 

 link to PsychINFO PsycINFO: Psychology and behavioral sciences database

link to CINAHL  Cumulative Index to Nursing and Allied Health Literature) Complete: Nursing & allied health database


ProQuest logo ProQuest Healthcare Administration Database: Health administration database

(Not available at USC SOM). Covers topics such as hospitals, insurance, law, statistics, business management, personnel management, ethics, health economics, and public health administration.

Embase logoEmbase:  A comprehensive database of biomedical research and literature.

link to SciFinder SciFinder:  Engineering, materials, biochemistry, synthesis & reactions, journal articles, patents, dissertations, chemical sources.


Scopus logoScopus: (Not available at USC SOM) Citation data, journal impact metrics, and journal indexing. Includes all of MEDLINE and Embase.

link to Web of ScienceWeb of Science: Includes Science Citation Index, Arts & Humanities Citation Index, and Journal Citation Reports.

 

  • AHRQ - Grants On Line Database

Government documents. Divided into various searches. Each search includes Portfolio/Program, Priority Population and indication of whether it is a Recovery Act project.

Collection of "scholarly" materials

  • Grey Literature Report (New York Academy of Medicine)

A quarterly list of gray literature documents in the field of public health.

  • Grey Matters: a practical search tool for evidence-based medicine

A tool for finding grey literature provided by the Canadian Agency for Drugs and Technologies in Health (CADTH).

  • Health Technology Assessment (HTA) Agencies

Custom Google search that searches International Health Technology websites compiled by the Canadian Agency for Drugs and technologies in Health.

  • NIH RePORTer

Government documents. Repository of intramural and extramural NIH-funded research projects. Access publications and patents resulting from NIH funding. In addition to NIH-funded research, the system provides access to research supported by the CDC, AHRQ, HRSA, SAMHSA and the VA.

Precision vs. Sensitivity in Systematic Reviews

Searches for systematic reviews aim to be as extensive as possible in order to ensure that as many as possible of the necessary and relevant studies are included in the review. It is, however, necessary to strike a balance between striving for comprehensiveness and maintaining relevance when developing a search strategy. Increasing the comprehensiveness (or sensitivity) of a search will reduce its precision and will retrieve more non-relevant articles.

Searches should seek high sensitivity, which may result in relatively low precision.

  • Recall (Sensitivity): The number of relevant reports identified divided by the total number of relevant reports in existence
  • Precision: The number of relevant reports identified divided by the total number of reports identified. 

More info: Higgins JPT, Green S (editors). Sensitivity versus precision (section 6.4.4) Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011]. The Cochrane Collaboration. Available from http://handbook-5-1.cochrane.org. Accessed June 1, 2018.

Documenting the Search

PRISMA Searching Checklist
The PRISMA Searching Checklist is the minimum set of items for reporting search details. The checklist includes 16 reporting items, each of which is detailed with exemplar reporting and rationale.

Documenting search details is a critical step in the systematic review process. If you collaborate with a librarian on your systematic review, the librarian will document all search details.

The following search details should be documented:

  • databases and resources searched
  • search strategies for each resource, including the search terms and limits used (e.g. dates, language, etc.)
  • the date each search was conducted
  • the number of results for each search strategy
  • notes on hand searching (e.g., any individual journals that were searched separately)

Documenting the search will ensure that we:

  • keep track of what we've done so that we don't repeat unproductive searches
  • reuse successful search strategies for future papers
  • help describe the search process for manuscripts
  • justify the search process